San Francisco 49ers 2021 schedule Predicting every game opponent win totals record projection

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With summer on the horizon, the 2021 NFL season will be here before you know it. And now that we've got full 17-game schedules available to us, what better way to ring in the biggest year in league history than by running through each and every matchup on the docket? Here, we're projecting the ' schedule, game by game, with win totals for every opponent. When will see his first action under center? Can the defense stay strong without Robert Saleh? Let's find out:Line: 49ers -7Opponent win total: O/U 5 is back under center for the 49ers, who support him with a big running game, a Chuma Edoga Jersey healthy and signature Kyle Shanahan game plan. , meanwhile, returns in full force to keep uncomfortable as he gets used to his new squad. Prediction: 49ers win 31-20Projected record:1-0Opponent win total:O/U 7Nick Sirianni's Eagles are brimming with energy in their home opener, and extends plays all afternoon. But Garoppolo is mostly comfortable targeting their young secondary, riding a few big plays to victory in Philly.Prediction: 49ers win 29-21Projected record:2-0Opponent win total:O/U N/A is still in Green Bay, having seized control of his future with the franchise, so this is no prime-time cakewalk for Shanahan, despite his history against Matt LaFleur. Forced to throw in a shootout, Garoppolo can't quite match No. 12.Prediction:49ers lose 28-24Projected record: 2-1 Opponent win total:O/U 10Shanahan dials up a heavy ground game to control the clock, but once again, the 49ers are stuck in a nail-biter with a great QB. , meanwhile, wins the final stretch thanks in part to his superior receiving corps, headlined by .Prediction: 49ers lose 26-23Projected record:2-2Opponent win total:O/U 8Kliff Kingsbury is under pre sure to deliver, and helps him out at home, rocketing big Sam Darnold Jersey throws into the 49ers' vulnerable secondary to force San Francisco to play from behind. and each score to lift the Cards.Prediction: 49ers lose 34-26Projected record: 2-3Opponent win total:O/U 10Three straight lo ses and a Week 6 bye prompt Shanahan to officially kick off the Trey Lance experiment. The rookie QB flashes in front of a fired-up crowd but is coaxed into two costly turnovers against a veteran Colts defense.Prediction: 49ers lose 24-20Projected record:2-4 Opponent win total:O/U 7.5The battle of the rookie QBs. is fresh on the scene just like Trey Lance, and he gets the benefit of home field here. Shanahan is better prepared than Matt Nagy, however, and leans on his run game and defense to eke out a tough win.Prediction: 49ers win 26-22Projected record:3-4Opponent win total:O/U 8The Cards still come out firing, with Kyler Murray creating on both the ground and through the air, but this time, Lance really shows his stuff as the centerpiece of Shanahan's dual-threat attack, weaving his way to and through Arizona's back seven.Prediction: 49ers win 31-27Projected record:4-4 Pick Six Newsletter Crafted By The Best NFL Experts Get the day's big stories + fun stuff you love like mock drafts, picks and power rankings. I agree to receive the "Pick Six Newsletter" and marketing communications, updates, special offers (including partner offers), and other information from CBS Sports and the Paramount family of companies. By pre sing sign up, I confirm that I have read and agree to the and acknowledge Paramount's . Please check the opt-in box to acknowledge that you would like to subscribe. Thanks for signing up! Keep an eye Isaiah Williams Jersey on your inbox. Sorry! There was an error proce sing your subscription. Opponent win total:O/U 10.5Fresh off the close win over Arizona, the 49ers get an even tougher challenge with Sean McVay's loaded offense in town. schemes up pre sure on , but in the end, L.A. is just too steady, often controlling the clock.Prediction: 49ers lose 27-20Projected record:4-5 Opponent win total:O/U 6 is a much tougher out than anticipated, finding on a handful of key downs to keep the Niners' secondary on its toes. Still, Jacksonville's defense is no match for Lance, and on the ground.Prediction: 49ers win 27-17Projected record:5-5Opponent win total:O/U 8.5 is a lightning-fast battering ram on the road, giving San Francisco's front all it can handle. But Shanahan comes prepared with yet another ground-based attack. Lance goes off with a career rushing performance in his home state of Minnesota.Prediction:49ers win 24-17Projected record: 6-5Opponent win total:O/U 10Fresh off a physical boxing match with Washington, the Seahawks play it safe to open the rematch. The 49ers, meanwhile, capitalize on an early fumble to take a quick lead, then spread the ball around to maintain the edge. Prediction: 49ers win 24-21Projected record: 7-5Opponent win total:O/U 6.5 ensures this one isn't a walk in the park, with , and all making splash plays to set up a potential upset. San Francisco is rarely stopped on offense, however, and the Niners win it late on a field goal.Prediction: 49ers win 29-26Projected record: 8-5Opponent win total:O/U 7.5Atlanta, once speculated as a landing spot for Lance, isn't just mi sing ; it's also still sorely in need of a defense. So Lance has a career day -- 350-plus pa sing yards and four total scores -- as the 49ers appear to hit their long-awaited stride.Prediction: 49ers win 41-27Projected record: 9-5Opponent win total:O/U 9.5Mike Vrabel's defense is feisty but not particularly good, allowing Shanahan to flip the script in Tenne see, where is bottled up for under 75 yards and instead Lance, Mostert, Sermon, and all flash on the ground. Prediction:49ers win 24-19Projected record: 10-5Opponent win total:O/U 4.5Houston is cycling through QBs while already looking ahead to a potential coaching and regime change (again). The 49ers take advantage, with Garoppolo even taking a handful of series late in this matchup as both sides of the ball cruise.Prediction: 49ers win 37-13Projected record: 11-5Opponent win total:O/U 10.5Once again, Sean McVay's squad is just a touch more experienced in key spots, like QB. This time, however, the Rams' O-line doesn't hold up nearly as well, and Matthew Stafford is baited into two picks. Lance mostly contributes on the ground, but it gets the job done.Prediction: 49ers win 27- Keelan Cole Jersey 24Projected record: 12-5
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